Preheat your oven to 350°F (175°C). Line a baking sheet with parchment paper if desired.
In a mixing bowl, combine the softened cream cheese and shredded cheddar cheese. Mix well until fully blended.
Add the all-purpose flour, garlic powder, onion powder, salt, and black pepper to the cheese mixture. Stir until it forms a sticky dough.
Using a spoon, scoop out approximately 2 tablespoons of the cheese mixture and roll it into a ball. Place the ball on the prepared baking sheet and slightly flatten it.
Using your thumb or the back of a spoon, press down in the center of each dough ball to create a small indentation.
Bake in the preheated oven for 15 minutes or until the edges are golden brown.
Remove the baking sheet from the oven and allow the appetizers to cool slightly for about 5 minutes.
Once cooled, spoon a small amount of hot pepper jelly into each thumbprint indentation.
Serve warm or at room temperature and enjoy your cheesy appetizers!