In a large pot of boiling salted water, cook the elbow macaroni according to package instructions until al dente. Drain and set aside.
In a medium saucepan, melt the butter over medium heat. Once melted, stir in the flour and whisk continuously for about 1 minute to create a roux.
Gradually add the milk while whisking constantly until the mixture thickens, about 5 minutes.
Remove the saucepan from heat and stir in the cheddar cheese, mozzarella cheese, garlic powder, onion powder, cayenne pepper, salt, and pepper until fully melted and smooth.
Add the drained macaroni to the cheese sauce and stir until well coated.
In a small bowl, combine panko breadcrumbs, olive oil, and grated Parmesan cheese. Mix until breadcrumbs are evenly coated.
Preheat the oven to 350°F (175°C). Transfer the mac and cheese mixture to a baking dish and evenly sprinkle the breadcrumb mixture on top.
Place the baking dish in the preheated oven and bake for 20 minutes, or until the top is golden brown and crispy.
Remove from the oven and let cool slightly. Serve warm, and enjoy the creamy, cheesy goodness!